Adolf Pfefferbaum

Title

Department
Psychiatry and Behavioral Sciences

Research Interests
Genetic and environmental influences on brain structure and function in healthy aging, alcoholism, Alzheimer's disease, and schizophrenia; MRI, fMRI, MRS, and DTI.

Email
dolf@synapse.sri.com

Phone

Fax

Address

Mail Code:

Faculty Research Description
Changes in brain structure and function in healthy aging, schizophrenia, alcoholism, and Alzheimer's Disease; diffusion tensor imaging of white matter microstructure in alcoholism; spectroscopic analysis of brain brain metabolite concentrations in alcoholism and Alzheimer's disease; functional neuroimaging of cognitive networks in alcoholism.

Menon V, Ford JM, Lim KO, Glover GH, Pfefferbaum A (1997): Combined fMRI and EEG evidence for temporal-parietal cortex activiation during target detection. NeuroReport 8:3029-3037.

Pfefferbaum, A, Sullivan, EV, Rosenbloom, MJ, Mathalon, DH, Lim, KO (1998): A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval. Archives of General Psychiatry 55:905-912.

Pfefferbaum, A, Adalsteinsson, E, Spielman, D, Sullivan, EV, Lim, KO (1999): In vivo quantification of N-acetyl aspartate (NA), creatine (Cr), and choline (Cho) from large volumes of gray matter and white matter on magnetic resonance spectroscopic images: Application to normal aging. Magnetic Resonance Medicine 41:276-284.

Pfefferbaum, A, Adalsteinsson, E, Spielman, D, Sullivan, EV, Lim, KO (1999). N-acetyl aspartate, creatine, and choline brain concentrations in Alzheimer's disease. Archives of General Psychiatry 56:185-192.

Pfefferbaum A, Sullivan EV, Swan GE, Carmelli D (2000): Brain structure in men remains highly heritable in the seventh and eighth decades of life. Neurobiology of Aging in press.

Areas of Study
SBRC