Mervyn Maze

Title
Faculty

Department
Anesthesia

Research Interests
Molecular pharmacology, regulation, structure and uses of human alpha-2 adrenergic receptors for anesthesia and analgesia.

Email
m.maze@lc.ac.uk

Phone
746-8025

Fax
746-8787

Address
3801 Miranda PA
Mail Code: 5588

Faculty Research Description
Molecular mechanism of anesthetic action. Signal transduction mechanism for the Alpha-2 adrenoceptor. Regulation of anesthetic and analgesic responses mediated at the Alpha-2 adrenergic receptor. Molecular modeling of the Alpha-2 adrenergic receptor Phase 1 through 3 studies examining the clinical efficacy of a novel Alpha-2 adrenergic agonist inhuman volunteers and patients

Seidel WF, Maze M, Dement WC, Edgar DM. Alpha-2 adrenergic modulation of sleep: time-of-day-dependent pharmacodynamic profiles of dexmedetomidine and clonidine in the rat. J. Pharmacol. Exp. Ther. 275:263-273, 1995.

Hayashi Y, Rabin BC, Guo T-Z, Maze M. The role of pertussis toxin-sensitive g proteins in the analgesic and anesthetic actions of a2 adrenergic agonists in the rat. Anesthesiol. 83:816-822, 1995.

Mizobe T, Maze M, Lam V, Suryanarayana S, Kobilka BK. Arrangement of transmembrane domains in adrenergic receptors: similarity to bacteriorhodopsin. J. Biol. Chem. 271:2387-2389, 1996.

Butterman AE, Maze M. Alpha-2 adrenergic agonists. Anesthesiol. Seminars in Anesthesia. 15:27-40, 1996.

Guo T-Z, Butterman AE, Jiang J-Y, Maze M. Dexmedetomidine injection into the locus coeruleus produces analgesia. Anesthesiol. 84:873-881, 1996.

Areas of Study
Cellular Neurobiology
Molecular Neurobiology
SBRC
Ph.D.